InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM66

Summary

InnateDB Protein

IDBP-30710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM66

Protein Name

tripartite motif containing 66

Synonyms

C11orf29; TIF1D; TIF1DELTA;

Species

Homo sapiens

Ensembl Protein

ENSP00000299550

InnateDB Gene

IDBG-30708 (TRIM66)

Protein Structure

UniProt Annotation

Function

May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0016235	aggresome

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR003649 B-box, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF00643
PF00439
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00336
SM00297
SM00249
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt