Version 5.4
Homo sapiens Protein: TCEB3B
Summary
InnateDB Protein IDBP-3075.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCEB3B
Protein Name transcription elongation factor B polypeptide 3B (elongin A2)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331302
InnateDB Gene IDBG-3073 (TCEB3B)
Protein Structure
UniProt Annotation
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269PubMed:10692460}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Specifically expressed in testis. {ECO:0000269PubMed:10692460}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0032784 regulation of DNA-templated transcription, elongation
Cellular Component
GO:0005634 nucleus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR010684 RNA polymerase II transcription factor SIII, subunit A
IPR017923 Transcription factor IIS, N-terminal
PFAM PF06881
PF08711
PRINTS
PIRSF
SMART SM00509
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IYF1
PhosphoSite PhosphoSite-Q8IYF1
TrEMBL
UniProt Splice Variant
Entrez Gene 51224
UniGene Hs.375035
RefSeq NP_057511
HUGO HGNC:30771
OMIM 609522
CCDS CCDS11932
HPRD 18169
IMGT
EMBL AB030834 BC036022
GenPept AAH36022 BAA90665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca