Version 5.4
Homo sapiens Protein: PDHA2
Summary
InnateDB Protein IDBP-30773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDHA2
Protein Name pyruvate dehydrogenase (lipoamide) alpha 2
Synonyms PDHAL;
Species Homo sapiens
Ensembl Protein ENSP00000295266
InnateDB Gene IDBG-30771 (PDHA2)
Protein Structure
UniProt Annotation
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269PubMed:16436377}.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity Testis. Expressed in postmeiotic spermatogenic cells. {ECO:0000269PubMed:22750801}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Biological Process
GO:0006006 glucose metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001017 Dehydrogenase, E1 component
IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR029061 Thiamin diphosphate-binding fold
PFAM PF00676
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29803
PhosphoSite PhosphoSite-P29803
TrEMBL
UniProt Splice Variant
Entrez Gene 5161
UniGene Hs.131361
RefSeq NP_005381
HUGO HGNC:8807
OMIM 179061
CCDS CCDS3644
HPRD 01531
IMGT
EMBL AK313872 BC030697 BC066953 BC094760 BC119656 BC119657 BC127637 BC127638 M86808
GenPept AAA60232 AAH30697 AAH66953 AAH94760 AAI19657 AAI19658 AAI27638 AAI27639 BAG36600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca