Version 5.4
Homo sapiens Protein: TNPO2
Summary
InnateDB Protein IDBP-30802.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNPO2
Protein Name transportin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349321
InnateDB Gene IDBG-30800 (TNPO2)
Protein Structure
UniProt Annotation
Function Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000357 HEAT
IPR001494 Importin-beta, N-terminal domain
IPR016024 Armadillo-type fold
PFAM PF02985
PF03810
PRINTS
PIRSF
SMART SM00913
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14787
PhosphoSite PhosphoSite-O14787
TrEMBL Q4LE60
UniProt Splice Variant
Entrez Gene 30000
UniGene Hs.714402
RefSeq NP_038461
HUGO HGNC:19998
OMIM 603002
CCDS CCDS45992
HPRD
IMGT
EMBL AB210011 AC018761 AF007748 AF019039 BC072420 CH471106
GenPept AAB71349 AAB83973 AAH72420 BAE06093 EAW84300 EAW84301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca