InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TTC3

Summary

InnateDB Protein

IDBP-3087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTC3

Protein Name

tetratricopeptide repeat domain 3

Synonyms

DCRR1; RNF105; TPRDIII;

Species

Homo sapiens

Ensembl Protein

ENSP00000347889

InnateDB Gene

IDBG-3083 (TTC3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. {ECO:0000269PubMed:17488780, ECO:0000269PubMed:20059950}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20059950}.

Disease Associations

Tissue Specificity

Found in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR011029 Death-like domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR018957 Zinc finger, C3HC4 RING-type
IPR019734 Tetratricopeptide repeat

PFAM

PF13639
PF14634
PF00097
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00184
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P53804