InnateDB Protein
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IDBP-30879.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BHMT2
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Protein Name
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betaine--homocysteine S-methyltransferase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000255192
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InnateDB Gene
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IDBG-30875 (BHMT2)
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Protein Structure
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Function |
Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. {ECO:0000269PubMed:18230605}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in liver and kidney and at reduced levels in the brain, heart, and skeletal muscle. {ECO:0000269PubMed:11087663}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008270
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zinc ion binding
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GO:0008898
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S-adenosylmethionine-homocysteine S-methyltransferase activity
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GO:0047150
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betaine-homocysteine S-methyltransferase activity
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GO:0061627
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S-methylmethionine-homocysteine S-methyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003726
Homocysteine S-methyltransferase
IPR017226
Betaine-homocysteine S-methyltransferase, BHMT
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PFAM |
PF02574
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PRINTS |
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PIRSF |
PIRSF037505
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H2M3
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PhosphoSite |
PhosphoSite-Q9H2M3
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TrEMBL |
E5RH96
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UniProt Splice Variant |
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Entrez Gene |
23743
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UniGene |
Hs.666242
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RefSeq |
NP_060084
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HUGO |
HGNC:1048
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OMIM |
605932
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CCDS |
CCDS4045
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HPRD |
12069
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IMGT |
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EMBL |
AC008502
AF257473
AK000008
AK298298
BC020665
CH471084
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GenPept |
AAG41356
AAH20665
BAA90880
BAH12752
EAW95829
EAW95830
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