InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESD

Summary

InnateDB Protein

IDBP-30918.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESD

Protein Name

esterase D

Synonyms

FGH;

Species

Homo sapiens

Ensembl Protein

ENSP00000367969

InnateDB Gene

IDBG-30914 (ESD)

Protein Structure

UniProt Annotation

Function

Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269PubMed:3770744, ECO:0000269PubMed:4768551}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008236	serine-type peptidase activity
GO:0018738	S-formylglutathione hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0046294	formaldehyde catabolic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000801 Putative esterase
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR008391 Acetyl xylan esterase
IPR014186 S-formylglutathione hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00756
PF00326
PF05448

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-P10768