InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BHMT

Summary

InnateDB Protein

IDBP-30926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BHMT

Protein Name

betaine--homocysteine S-methyltransferase

Synonyms

BHMT1; HEL-S-61p;

Species

Homo sapiens

Ensembl Protein

ENSP00000274353

InnateDB Gene

IDBG-30922 (BHMT)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Found exclusively in liver and kidney. {ECO:0000269PubMed:9281325}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0032403	protein complex binding
GO:0047150	betaine-homocysteine S-methyltransferase activity
GO:0061627	S-methylmethionine-homocysteine S-methyltransferase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006479	protein methylation
GO:0006577	amino-acid betaine metabolic process
GO:0006579	amino-acid betaine catabolic process
GO:0009086	methionine biosynthetic process
GO:0010243	response to organonitrogen compound
GO:0033477	S-methylmethionine metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0050666	regulation of homocysteine metabolic process
GO:0071267	L-methionine salvage