InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST8SIA2

Summary

InnateDB Protein

IDBP-30947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST8SIA2

Protein Name

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Synonyms

HsT19690; SIAT8B; ST8SIA-II; STX;

Species

Homo sapiens

Ensembl Protein

ENSP00000268164

InnateDB Gene

IDBG-30945 (ST8SIA2)

Protein Structure

UniProt Annotation

Function

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373	sialyltransferase activity
GO:0033691	sialic acid binding

Biological Process

GO:0001574	ganglioside biosynthetic process
GO:0005975	carbohydrate metabolic process
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006491	N-glycan processing
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0009311	oligosaccharide metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0097503	sialylation