InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDX2

Summary

InnateDB Protein

IDBP-31026.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX2

Protein Name

peroxiredoxin 2

Synonyms

HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA;

Species

Homo sapiens

Ensembl Protein

ENSP00000301522

InnateDB Gene

IDBG-31024 (PRDX2)

Protein Structure

UniProt Annotation

Function

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0006979	response to oxidative stress
GO:0019430	removal of superoxide radicals
GO:0034599	cellular response to oxidative stress
GO:0042744	hydrogen peroxide catabolic process
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal

PFAM