Version 5.4
Homo sapiens Protein: IER3IP1
Summary
InnateDB Protein IDBP-3103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IER3IP1
Protein Name immediate early response 3 interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256433
InnateDB Gene IDBG-3101 (IER3IP1)
Protein Structure
UniProt Annotation
Function May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15276200}; Multi-pass membrane protein {ECO:0000269PubMed:15276200}.
Disease Associations Microcephaly, epilepsy, and diabetes syndrome (MEDS) [MIM:614231]: An autosomal recessive disorder characterized by microcephaly, simplified gyral pattern, severe epilepsy, and infantile diabetes. {ECO:0000269PubMed:21835305}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highest levels in heart, skeletal muscle, and kidney. {ECO:0000269PubMed:15276200}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:2000269 regulation of fibroblast apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013880 Yos1-like
PFAM PF08571
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5U9
PhosphoSite PhosphoSite-Q9Y5U9
TrEMBL
UniProt Splice Variant
Entrez Gene 51124
UniGene Hs.720715
RefSeq NP_057181
HUGO HGNC:18550
OMIM 609382
CCDS CCDS11933
HPRD 13727
IMGT
EMBL AF125100 AF164798 AF371963 AL136667 BC010888 BC017391 CR533488
GenPept AAD39917 AAF80762 AAH10888 AAH17391 AAK53816 CAB66602 CAG38519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca