InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A8

Summary

InnateDB Protein

IDBP-3106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A8

Protein Name

solute carrier family 7 (amino acid transporter light chain, L system), member 8

Synonyms

LAT2; LPI-PC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000320378

InnateDB Gene

IDBG-3104 (SLC7A8)

Protein Structure

UniProt Annotation

Function

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. {ECO:0000269PubMed:10391915, ECO:0000269PubMed:10574970, ECO:0000269PubMed:11311135, ECO:0000269PubMed:12117417, ECO:0000269PubMed:12716892, ECO:0000269PubMed:15081149, ECO:0000269PubMed:15769744, ECO:0000269PubMed:15918515}.

Subcellular Localization

Cytoplasm. Basolateral cell membrane; Multi- pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.

Disease Associations

Tissue Specificity

Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2. {ECO:0000269PubMed:10391915, ECO:0000269PubMed:15081149, ECO:0000269PubMed:15918515, ECO:0000269PubMed:16027961}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015101	organic cation transmembrane transporter activity
GO:0015171	amino acid transmembrane transporter activity
GO:0015175	neutral amino acid transmembrane transporter activity
GO:0015179	L-amino acid transmembrane transporter activity
GO:0019534	toxin transporter activity
GO:0042605	peptide antigen binding

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006520	cellular amino acid metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0007596	blood coagulation
GO:0009636	response to toxic substance
GO:0015695	organic cation transport
GO:0015804	neutral amino acid transport
GO:0015807	L-amino acid transport
GO:0050900	leukocyte migration
GO:0055065	metal ion homeostasis
GO:0055085	transmembrane transport
GO:1901998	toxin transport
GO:1902475	L-alpha-amino acid transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome