Homo sapiens Protein: RGMA
Summary
InnateDB Protein IDBP-31196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGMA
Protein Name RGM domain family, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330005
InnateDB Gene IDBG-31194 (RGMA)
Protein Structure
UniProt Annotation
Function Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269PubMed:19273616, ECO:0000269PubMed:19458235}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007411 axon guidance
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009496 Repulsive guidance molecule, C-terminal
IPR010536 Repulsive guidance molecule, N-terminal
PFAM PF06534
PF06535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96B86
PhosphoSite PhosphoSite-Q96B86
TrEMBL G3V4C2
UniProt Splice Variant
Entrez Gene 56963
UniGene
RefSeq NP_064596
HUGO HGNC:30308
OMIM 607362
CCDS CCDS45357
HPRD 09560
IMGT
EMBL AC087641 AK074910 AK074966 AK074980 AK299363 AL136826 AL390083 BC015886 BC140838 BC151132 CH471101
GenPept AAH15886 AAI40839 AAI51133 BAC11285 BAC11321 BAC11330 BAH13014 CAB66760 CAB98207 EAX02167