Version 5.4
Homo sapiens Protein: SWAP70
Summary
InnateDB Protein IDBP-31468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SWAP70
Protein Name SWAP switching B-cell complex 70kDa subunit
Synonyms SWAP-70;
Species Homo sapiens
Ensembl Protein ENSP00000315630
InnateDB Gene IDBG-31466 (SWAP70)
Protein Structure
UniProt Annotation
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Disease Associations
Tissue Specificity Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). {ECO:0000269PubMed:10681448, ECO:0000269PubMed:12925760}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0016444 somatic cell DNA recombination
GO:0045087 innate immune response
GO:0045190 isotype switching
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
PFAM PF00169
PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00233
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UH65
PhosphoSite PhosphoSite-Q9UH65
TrEMBL E9PJM7
UniProt Splice Variant
Entrez Gene 23075
UniGene Hs.153026
RefSeq NP_055870
HUGO HGNC:17070
OMIM 604762
CCDS CCDS31426
HPRD 10378
IMGT
EMBL AB014540 AC011979 AC026250 AF134894 AF161439 AF210818 BC000616 CH471064
GenPept AAF24486 AAF28999 AAF61403 AAH00616 BAA31615 EAW68582 EAW68583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca