Version 5.4
Homo sapiens Protein: GADD45GIP1
Summary
InnateDB Protein IDBP-31571.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GADD45GIP1
Protein Name growth arrest and DNA-damage-inducible, gamma interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323065
InnateDB Gene IDBG-31569 (GADD45GIP1)
Protein Structure
UniProt Annotation
Function Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Localization Mitochondrion. Nucleus. Note=Using N- terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269PubMed:12482659, ECO:0000269PubMed:22453275}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. {ECO:0000269PubMed:12716909}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR018472 Growth arrest/ DNA-damage-inducible protein-interacting protein 1
PFAM PF10147
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAE8
PhosphoSite PhosphoSite-Q8TAE8
TrEMBL Q7LAX7
UniProt Splice Variant
Entrez Gene 90480
UniGene
RefSeq NP_443082
HUGO HGNC:29996
OMIM 605162
CCDS CCDS12290
HPRD 05519
IMGT
EMBL AF147080 AF412816 AF475095 AF479749 AJ295986 AJ429498 BC004944 BC013027 BC013039 BC069200
GenPept AAH04944 AAH13027 AAH13039 AAH69200 AAL55291 AAL85877 AAM10639 CAC82499 CAD22344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca