InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RDH14

Summary

InnateDB Protein

IDBP-31659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDH14

Protein Name

retinol dehydrogenase 14 (all-trans/9-cis/11-cis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370648

InnateDB Gene

IDBG-403877 (RDH14)

Protein Structure

UniProt Annotation

Function

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected. {ECO:0000269PubMed:12226107}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain, kidney, pancreas and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016491	oxidoreductase activity
GO:0050662	coenzyme binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF01370
PF00106
PF08659

PRINTS

PR00080
PR00081

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt