InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CKMT2

Summary

InnateDB Protein

IDBP-31736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKMT2

Protein Name

creatine kinase, mitochondrial 2 (sarcomeric)

Synonyms

SMTCK;

Species

Homo sapiens

Ensembl Protein

ENSP00000254035

InnateDB Gene

IDBG-31732 (CKMT2)

Protein Structure

UniProt Annotation

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Disease Associations

Tissue Specificity

Sarcomere-specific. Found only in heart and skeletal muscles.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004111	creatine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006600	creatine metabolic process
GO:0006936	muscle contraction
GO:0016310	phosphorylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process