Version 5.4
Homo sapiens Protein: DDIT4L
Summary
InnateDB Protein IDBP-31742.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDIT4L
Protein Name DNA-damage-inducible transcript 4-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354830
InnateDB Gene IDBG-31740 (DDIT4L)
Protein Structure
UniProt Annotation
Function Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. {ECO:0000269PubMed:15545625, ECO:0000269PubMed:15632201}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery. {ECO:0000269PubMed:15308555}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009968 negative regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR012918 RTP801-like
PFAM PF07809
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96D03
PhosphoSite PhosphoSite-Q96D03
TrEMBL D6RJ99
UniProt Splice Variant
Entrez Gene 115265
UniGene Hs.627076
RefSeq NP_660287
HUGO HGNC:30555
OMIM 607730
CCDS CCDS34036
HPRD 09663
IMGT
EMBL AK094236 AK312926 AL832277 AP001961 BC013592 CH471057
GenPept AAH13592 BAC04315 BAG35770 CAI46176 EAX06119

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca