Version 5.4
Homo sapiens Protein: EMCN
Summary
InnateDB Protein IDBP-31759.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EMCN
Protein Name endomucin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296420
InnateDB Gene IDBG-31757 (EMCN)
Protein Structure
UniProt Annotation
Function Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.Isoform 2: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in heart, kidney and lung. {ECO:0000269PubMed:11418125, ECO:0000269PubMed:12485444}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR010740 Endomucin
PFAM PF07010
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ULC0
PhosphoSite PhosphoSite-Q9ULC0
TrEMBL Q53H40
UniProt Splice Variant
Entrez Gene 51705
UniGene Hs.630407
RefSeq NP_057326
HUGO HGNC:16041
OMIM 608350
CCDS CCDS3655
HPRD 12220
IMGT
EMBL AB034695 AC034150 AC097459 AC115623 AC116174 AC138606 AF205940 AK222741 AK291831 AK304568 AK313504 AP001964 AY039241 BC017781 CH471057
GenPept AAF76295 AAH17781 AAK68660 AAY41011 BAA86228 BAD96461 BAF84520 BAG36284 BAG65359 EAX06121 EAX06122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca