Version 5.4
Homo sapiens Protein: GIGYF1
Summary
InnateDB Protein IDBP-31833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIGYF1
Protein Name GRB10 interacting GYF protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000275732
InnateDB Gene IDBG-31831 (GIGYF1)
Protein Structure
UniProt Annotation
Function May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003169 GYF
PFAM PF02213
PRINTS
PIRSF
SMART SM00444
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75420
PhosphoSite PhosphoSite-O75420
TrEMBL
UniProt Splice Variant
Entrez Gene 64599
UniGene Hs.721569
RefSeq NP_072096
HUGO HGNC:9126
OMIM 612064
CCDS CCDS34708
HPRD 10145
IMGT
EMBL AF053356 AF289554 AY176044
GenPept AAC78792 AAL55738 AAO46888

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca