InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NACC1

Summary

InnateDB Protein

IDBP-31851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NACC1

Protein Name

nucleus accumbens associated 1, BEN and BTB (POZ) domain containing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292431

InnateDB Gene

IDBG-31849 (NACC1)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269PubMed:17130457, ECO:0000269PubMed:17804717}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. {ECO:0000269PubMed:17130457, ECO:0000269PubMed:17391728}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051260	protein homooligomerization