InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A17

Summary

InnateDB Protein

IDBP-3189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A17

Protein Name

solute carrier family 22, member 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000206544

InnateDB Gene

IDBG-3187 (SLC22A17)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17253959}; Multi-pass membrane protein {ECO:0000269PubMed:17253959}. Vacuole membrane {ECO:0000269PubMed:17253959}; Multi-pass membrane protein {ECO:0000269PubMed:17253959}. Note=Upon LCN2-binding, it is internalized.

Disease Associations

Tissue Specificity

Expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0007165	signal transduction
GO:0015891	siderophore transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005774	vacuolar membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031301	integral component of organelle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WUG5

PhosphoSite