InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADORA2B

Summary

InnateDB Protein

IDBP-31922.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA2B

Protein Name

adenosine A2b receptor

Synonyms

ADORA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000304501

InnateDB Gene

IDBG-31920 (ADORA2B)

Protein Structure

UniProt Annotation

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0001973	adenosine receptor signaling pathway
GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007254	JNK cascade
GO:0007588	excretion
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0031284	positive regulation of guanylate cyclase activity
GO:0031668	cellular response to extracellular stimulus
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0043306	positive regulation of mast cell degranulation
GO:0060087	relaxation of vascular smooth muscle

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001435 Adenosine A2B receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00554
PR00424

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29275