InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCSTAMP

Summary

InnateDB Protein

IDBP-32023.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCSTAMP

Protein Name

transmembrane 7 superfamily member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297581

InnateDB Gene

IDBG-32021 (DCSTAMP)

Protein Structure

UniProt Annotation

Function

Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes. {ECO:0000269PubMed:11169400, ECO:0000269PubMed:11345586}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006810	transport
GO:0030308	negative regulation of cell growth
GO:0030316	osteoclast differentiation
GO:0034241	positive regulation of macrophage fusion
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0043011	myeloid dendritic cell differentiation
GO:0045657	positive regulation of monocyte differentiation
GO:0045780	positive regulation of bone resorption
GO:0055085	transmembrane transport
GO:0061025	membrane fusion
GO:0071353	cellular response to interleukin-4
GO:0071356	cellular response to tumor necrosis factor
GO:0072675	osteoclast fusion

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane