Version 5.4
Homo sapiens Protein: MT2A
Summary
InnateDB Protein IDBP-32156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MT2A
Protein Name metallothionein 2A
Synonyms MT2;
Species Homo sapiens
Ensembl Protein ENSP00000245185
InnateDB Gene IDBG-32154 (MT2A)
Protein Structure
UniProt Annotation
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 22 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006878 cellular copper ion homeostasis
GO:0019221 cytokine-mediated signaling pathway
GO:0035690 cellular response to drug
GO:0036016 cellular response to interleukin-3
GO:0036018 cellular response to erythropoietin
GO:0045926 negative regulation of growth
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071294 cellular response to zinc ion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000006 Metallothionein, vertebrate
IPR003019 Metallothionein superfamily, eukaryotic
IPR017854 Metallothionein domain
PFAM PF00131
PRINTS PR00860
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02795
PhosphoSite PhosphoSite-P02795
TrEMBL
UniProt Splice Variant
Entrez Gene 4502
UniGene
RefSeq NP_005944
HUGO HGNC:7406
OMIM 156360
CCDS CCDS10763
HPRD 08863
IMGT
EMBL BC007034 BC070289 BT007315 DQ370420 J00271 M26637 S52379 V00594 X97260
GenPept AAA59583 AAA59584 AAB24908 AAH07034 AAH70289 AAP35979 ABC79300 CAA23841 CAA65915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca