InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDC1

Summary

InnateDB Protein

IDBP-32198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDC1

Protein Name

syndecan 1

Synonyms

CD138; SDC; SYND1; syndecan;

Species

Homo sapiens

Ensembl Protein

ENSP00000254351

InnateDB Gene

IDBG-32196 (SDC1)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0042157	lipoprotein metabolic process
GO:0044281	small molecule metabolic process
GO:0048627	myoblast development
GO:0055002	striated muscle cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome