InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MT1A

Summary

InnateDB Protein

IDBP-32246.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MT1A

Protein Name

metallothionein 1A

Synonyms

MT1; MT1S; MTC;

Species

Homo sapiens

Ensembl Protein

ENSP00000290705

InnateDB Gene

IDBG-32244 (MT1A)

Protein Structure

UniProt Annotation

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0045926	negative regulation of growth
GO:0071276	cellular response to cadmium ion
GO:0071294	cellular response to zinc ion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000006 Metallothionein, vertebrate
IPR003019 Metallothionein superfamily, eukaryotic
IPR017854 Metallothionein domain

PFAM

PF00131

PRINTS

PR00860

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04731

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

4489

UniGene

RefSeq

NP_005937

HUGO

HGNC:7393

OMIM

156350

CCDS

CCDS32454

HPRD

07035

IMGT

EMBL

AC026461 AF348995 AY028617 BC029475 K01383

GenPept

AAA59586 AAH29475 AAK26162 AAO32955