InnateDB Protein
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IDBP-32263.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ASIC1
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Protein Name
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amiloride-sensitive cation channel 2, neuronal
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Synonyms
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ACCN2; ASIC; BNaC2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000228468
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InnateDB Gene
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IDBG-32261 (ASIC1)
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Protein Structure
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Function |
Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. {ECO:0000269PubMed:22760635}.Isoform 1 does not display proton-gated cation channel activity. {ECO:0000269PubMed:22760635}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:12578970, ECO:0000269PubMed:21036899, ECO:0000269PubMed:22760635}; Multi- pass membrane protein {ECO:0000269PubMed:12578970, ECO:0000269PubMed:21036899, ECO:0000269PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in most or all neurons.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001873
Na+ channel, amiloride-sensitive
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PFAM |
PF00858
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PRINTS |
PR01078
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P78348
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PhosphoSite |
PhosphoSite-P78348
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
41
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UniGene |
Hs.274361
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RefSeq |
NP_064423
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HUGO |
HGNC:100
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OMIM |
602866
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CCDS |
CCDS8796
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HPRD |
04182
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IMGT |
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EMBL |
AC025154
BC013891
BC133707
CH471111
EU078959
HM991481
U78180
U78181
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GenPept |
AAB48980
AAB48981
AAH13891
AAI33708
ABU48925
ADP44689
EAW58118
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