Version 5.4
Homo sapiens Protein: MT1B
Summary
InnateDB Protein IDBP-32291.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MT1B
Protein Name metallothionein 1B
Synonyms MT1; MT1Q; MTP;
Species Homo sapiens
Ensembl Protein ENSP00000334998
InnateDB Gene IDBG-32289 (MT1B)
Protein Structure
UniProt Annotation
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0045926 negative regulation of growth
GO:0071294 cellular response to zinc ion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000006 Metallothionein, vertebrate
IPR003019 Metallothionein superfamily, eukaryotic
IPR017854 Metallothionein domain
PFAM PF00131
PRINTS PR00860
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07438
PhosphoSite PhosphoSite-P07438
TrEMBL
UniProt Splice Variant
Entrez Gene 4490
UniGene
RefSeq NP_005938
HUGO HGNC:7394
OMIM 156349
CCDS CCDS10765
HPRD 11826
IMGT
EMBL AF349000 AF350250 AY168638 BC069421 BC137478 BC137479 M13484 M13485
GenPept AAA36331 AAH69421 AAI37479 AAI37480 AAN86984 AAO32960 AAO49186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca