Homo sapiens Protein: ZNF589
Summary
InnateDB Protein IDBP-32373.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF589
Protein Name zinc finger protein 589
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346729
InnateDB Gene IDBG-32371 (ZNF589)
Protein Structure
UniProt Annotation
Function May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor. {ECO:0000269PubMed:10029171, ECO:0000269PubMed:12097288}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23665872}.
Disease Associations
Tissue Specificity Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells. {ECO:0000269PubMed:10029171}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UQ0
PhosphoSite PhosphoSite-Q86UQ0
TrEMBL Q59FS2
UniProt Splice Variant
Entrez Gene 51385
UniGene Hs.172602
RefSeq NP_057173
HUGO HGNC:16747
OMIM
CCDS CCDS43085
HPRD 15865
IMGT
EMBL AB209387 AF114816 AF114817 AL832831 AY258146 BC005859 BC006247 BC048798 CH471055
GenPept AAD38879 AAD38880 AAH05859 AAH06247 AAH48798 AAP14679 BAD92624 CAI46129 EAW64856