InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MT1H

Summary

InnateDB Protein

IDBP-32404.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MT1H

Protein Name

metallothionein 1H

Synonyms

MT-0; MT-1H; MT-IH; MT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000330587

InnateDB Gene

IDBG-32402 (MT1H)

Protein Structure

UniProt Annotation

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0045926	negative regulation of growth
GO:0071276	cellular response to cadmium ion
GO:0071294	cellular response to zinc ion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000006 Metallothionein, vertebrate
IPR003019 Metallothionein superfamily, eukaryotic
IPR017854 Metallothionein domain

PFAM

PF00131

PRINTS

PR00860

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P80294

PhosphoSite

PhosphoSite-P80294

TrEMBL

UniProt Splice Variant

Entrez Gene

4496

UniGene

Hs.632513

RefSeq

NP_005942

HUGO

HGNC:7400

OMIM

156354

CCDS

CCDS10767

HPRD

01128

IMGT

EMBL

BC008408 BC059780 BC146930 BC146934 BT007171 CH471092 S68948 X64177 X64834

GenPept

AAB30081 AAH08408 AAH59780 AAI46931 AAI46935 AAP35835 CAA45516 CAA46046 EAW82884