InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPD1

Summary

InnateDB Protein

IDBP-32407.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPD1

Protein Name

glycerol-3-phosphate dehydrogenase 1 (soluble)

Synonyms

GPD-C; GPDH-C; HTGTI;

Species

Homo sapiens

Ensembl Protein

ENSP00000301149

InnateDB Gene

IDBG-32405 (GPD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]: An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. {ECO:0000269PubMed:22226083}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0004368	glycerol-3-phosphate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006094	gluconeogenesis
GO:0006116	NADH oxidation
GO:0006127	glycerophosphate shuttle
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006734	NADH metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045821	positive regulation of glycolytic process
GO:0046168	glycerol-3-phosphate catabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0046486	glycerolipid metabolic process
GO:0055114	oxidation-reduction process
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0009331	glycerol-3-phosphate dehydrogenase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic

PFAM

PF07479
PF01210

PRINTS

PR00077

PIRSF

PIRSF000114

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt