Version 5.4
Homo sapiens Protein: BDH2
Summary
InnateDB Protein IDBP-32421.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BDH2
Protein Name 3-hydroxybutyrate dehydrogenase, type 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296424
InnateDB Gene IDBG-32419 (BDH2)
Protein Structure
UniProt Annotation
Function Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16380372}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0019290 siderophore biosynthetic process
GO:0030855 epithelial cell differentiation
GO:0042168 heme metabolic process
GO:0055072 iron ion homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PFAM PF00106
PRINTS PR00080
PR00081
PR01167
PR01397
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BUT1
PhosphoSite PhosphoSite-Q9BUT1
TrEMBL D6RIR6
UniProt Splice Variant
Entrez Gene 56898
UniGene Hs.124696
RefSeq NP_064524
HUGO HGNC:32389
OMIM
CCDS CCDS3663
HPRD 07103
IMGT
EMBL AC097485 AF164790 AK023323 AK290160 AK300626 AY358841 BC001953 BC037277 BC095414 CH471057 CR457309
GenPept AAF80754 AAH01953 AAH37277 AAH95414 AAQ89200 BAB14526 BAF82849 BAG62318 CAG33590 EAX06164 EAX06167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca