InnateDB Protein
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IDBP-32492.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CENPE
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Protein Name
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centromere protein E, 312kDa
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Synonyms
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CENP-E; KIF10; PPP1R61;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369365
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InnateDB Gene
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IDBG-32488 (CENPE)
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Protein Structure
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Function |
Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle. {ECO:0000269PubMed:17535814, ECO:0000269PubMed:7889940}.
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Subcellular Localization |
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001752
Kinesin, motor domain
IPR015988
STAT transcription factor, coiled coil
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
Q02224
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PhosphoSite |
PhosphoSite-Q02224
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1062
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UniGene |
Hs.75573
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RefSeq |
NP_001273663
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HUGO |
HGNC:1856
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OMIM |
117143
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CCDS |
CCDS68768
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HPRD |
00316
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IMGT |
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EMBL |
AB209996
AC079919
AK290362
CH471057
Z15005
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GenPept |
BAE06078
BAF83051
CAA78727
EAX06171
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