Version 5.4
Homo sapiens Protein: TMEM74
Summary
InnateDB Protein IDBP-32500.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM74
Protein Name transmembrane protein 74
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000297459
InnateDB Gene IDBG-32498 (TMEM74)
Protein Structure
UniProt Annotation
Function Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. {ECO:0000269PubMed:18294959, ECO:0000269PubMed:19029833}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:18294959}; Multi-pass membrane protein {ECO:0000269PubMed:18294959}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269PubMed:18294959}; Multi-pass membrane protein {ECO:0000269PubMed:18294959}.
Disease Associations
Tissue Specificity Expressed in heart, lung, and placenta. {ECO:0000269PubMed:18294959}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006914 autophagy
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NL1
PhosphoSite PhosphoSite-
TrEMBL A0A024R9D4
UniProt Splice Variant
Entrez Gene 157753
UniGene Hs.99439
RefSeq NP_694560
HUGO HGNC:26409
OMIM 613935
CCDS CCDS6310
HPRD 08702
IMGT
EMBL AK055230 BC030710 CH471060
GenPept AAH30710 BAB70881 EAW91921 EAW91922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca