Version 5.4
Homo sapiens Protein: MPRIP
Summary
InnateDB Protein IDBP-32636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPRIP
Protein Name myosin phosphatase Rho interacting protein
Synonyms M-RIP; MRIP; p116Rip; RHOIP3; RIP3;
Species Homo sapiens
Ensembl Protein ENSP00000342379
InnateDB Gene IDBG-32634 (MPRIP)
Protein Structure
UniProt Annotation
Function Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250UniProtKB:P97434, ECO:0000269PubMed:15545284, ECO:0000269PubMed:16257966}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:14506264, ECO:0000269PubMed:16257966}. Note=Colocalizes with F-actin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR009078 Ferritin-like superfamily
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6WCQ1
PhosphoSite PhosphoSite-Q6WCQ1
TrEMBL Q8N236
UniProt Splice Variant
Entrez Gene 23164
UniGene
RefSeq NP_958431
HUGO HGNC:30321
OMIM 612935
CCDS CCDS32578
HPRD 17591
IMGT
EMBL AB098507 AB189741 AC055811 AC079111 AJ844625 AK092287 AL834513 AY296247 BC009982 BC075847 BC105987
GenPept AAH09982 AAH75847 AAI05988 AAQ63176 BAC03851 BAC78198 BAD89507 CAD39169 CAH59751

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca