InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACAA2

Summary

InnateDB Protein

IDBP-3282.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAA2

Protein Name

acetyl-CoA acyltransferase 2

Synonyms

DSAEC;

Species

Homo sapiens

Ensembl Protein

ENSP00000285093

InnateDB Gene

IDBG-3280 (ACAA2)

Protein Structure

UniProt Annotation

Function

Abolishes BNIP3-mediated apoptosis and mitochondrial damage. {ECO:0000269PubMed:18371312}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:18371312}. Note=Colocalizes with BNIP3 in the mitochondria.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003988	acetyl-CoA C-acyltransferase activity
GO:0005515	protein binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0008152	metabolic process
GO:0071456	cellular response to hypoxia
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process