InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNV1

Summary

InnateDB Protein

IDBP-32852.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNV1

Protein Name

potassium channel, subfamily V, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297404

InnateDB Gene

IDBG-32850 (KCNV1)

Protein Structure

UniProt Annotation

Function

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. {ECO:0000269PubMed:8670833, ECO:0000269PubMed:9079713}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:8670833, ECO:0000269PubMed:9079713}; Multi-pass membrane protein {ECO:0000269PubMed:8670833, ECO:0000269PubMed:9079713}. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.

Disease Associations

Tissue Specificity

Detected in brain. {ECO:0000269PubMed:12383276}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0008200	ion channel inhibitor activity
GO:0015459	potassium channel regulator activity

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003970 Potassium channel, voltage dependent, Kv8.1
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003974 Potassium channel, voltage dependent, Kv3
IPR003975 Potassium channel, voltage dependent, Kv4
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain

PFAM

PF02214
PF00520
PF07885

PRINTS