InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTH

Summary

InnateDB Protein

IDBP-32893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTH

Protein Name

parathyroid hormone

Synonyms

PTH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000282091

InnateDB Gene

IDBG-32891 (PTH)

Protein Structure

UniProt Annotation

Function

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. {ECO:0000269PubMed:21076856}.

Subcellular Localization

Secreted.

Disease Associations

Hypoparathyroidism, familial isolated (FIH) [MIM:146200]: A disorder characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Clinical features include seizures, tetany and cramps. {ECO:0000269PubMed:10523031, ECO:0000269PubMed:2212001}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005179	hormone activity
GO:0031856	parathyroid hormone receptor binding
GO:0031857	type 1 parathyroid hormone receptor binding
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0006366	transcription from RNA polymerase II promoter
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007267	cell-cell signaling
GO:0008628	hormone-mediated apoptotic signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0030501	positive regulation of bone mineralization
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031667	response to nutrient levels
GO:0033280	response to vitamin D
GO:0034645	cellular macromolecule biosynthetic process
GO:0042493	response to drug
GO:0045453	bone resorption
GO:0045471	response to ethanol
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045778	positive regulation of ossification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046058	cAMP metabolic process
GO:0046326	positive regulation of glucose import
GO:0046686	response to cadmium ion
GO:0071107	response to parathyroid hormone
GO:0071774	response to fibroblast growth factor