Version 5.4
Homo sapiens Protein: COPS3
Summary
InnateDB Protein IDBP-32913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS3
Protein Name COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
Synonyms CSN3; SGN3;
Species Homo sapiens
Ensembl Protein ENSP00000268717
InnateDB Gene IDBG-32911 (COPS3)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:9535219}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9535219}. Nucleus {ECO:0000269PubMed:9535219}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269PubMed:10191102}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 93 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007165 signal transduction
GO:0009416 response to light stimulus
GO:0010388 cullin deneddylation
Cellular Component
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID
InterPro IPR000717 Proteasome component (PCI) domain
PFAM PF01399
PRINTS
PIRSF
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UNS2
PhosphoSite PhosphoSite-Q9UNS2
TrEMBL J3QKR0
UniProt Splice Variant
Entrez Gene 8533
UniGene Hs.6076
RefSeq NP_003644
HUGO HGNC:2239
OMIM 604665
CCDS CCDS11183
HPRD 07262
IMGT
EMBL AC055811 AF031647 AF098109 AK302304 AK312476 AK316400 BC001891 CH471196
GenPept AAC14197 AAD41247 AAH01891 BAG35380 BAG63643 BAH14771 EAW55712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca