Version 5.4
Homo sapiens Protein: FAR1
Summary
InnateDB Protein IDBP-32940.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAR1
Protein Name fatty acyl CoA reductase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346874
InnateDB Gene IDBG-32934 (FAR1)
Protein Structure
UniProt Annotation
Function Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. {ECO:0000269PubMed:15220348}.
Subcellular Localization Peroxisome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0050062 long-chain-fatty-acyl-CoA reductase activity
GO:0050662 coenzyme binding
GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity
Biological Process
GO:0008611 ether lipid biosynthetic process
GO:0010025 wax biosynthetic process
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR013120 Male sterility, NAD-binding
IPR026055 Fatty acyl-CoA reductase
PFAM PF01370
PF07993
PF03015
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVX9
PhosphoSite PhosphoSite-Q8WVX9
TrEMBL E9PPB8
UniProt Splice Variant
Entrez Gene 84188
UniGene Hs.700380
RefSeq NP_115604
HUGO HGNC:26222
OMIM
CCDS CCDS7813
HPRD 14724
IMGT
EMBL AC013828 AC026843 AY358784 AY423606 AY600449 BC017377 CH471064 CR936619
GenPept AAH17377 AAQ89144 AAR84086 AAT42129 CAI56762 EAW68492 EAW68493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca