InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM56

Summary

InnateDB Protein

IDBP-32958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM56

Protein Name

tripartite motif containing 56

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000305161

InnateDB Gene

IDBG-32956 (TRIM56)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of type I interferon IFN- beta following detection of pathogen- and host-derived double- stranded DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032608	interferon-beta production
GO:0034340	response to type I interferon
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0070534	protein K63-linked ubiquitination
GO:1902187	negative regulation of viral release from host cell