Version 5.4
Homo sapiens Protein: MED9
Summary
InnateDB Protein IDBP-32983.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED9
Protein Name mediator complex subunit 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000268711
InnateDB Gene IDBG-32981 (MED9)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
Experimentally validated
Total 58 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR011425 Mediator complex, subunit Med9
PFAM PF07544
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWA0
PhosphoSite PhosphoSite-Q9NWA0
TrEMBL
UniProt Splice Variant
Entrez Gene 55090
UniGene Hs.244595
RefSeq NP_060489
HUGO HGNC:25487
OMIM 609878
CCDS CCDS11184
HPRD 14383
IMGT
EMBL AK001055 BC104988 BC112029 CH471196
GenPept AAI04989 AAI12030 BAA91483 EAW55706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca