InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPHN1

Summary

InnateDB Protein

IDBP-33010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPHN1

Protein Name

latrophilin 1

Synonyms

CIRL1; CL1; LEC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000340688

InnateDB Gene

IDBG-33008 (LPHN1)

Protein Structure

UniProt Annotation

Function

Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016524	latrotoxin receptor activity
GO:0030246	carbohydrate binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0090129	positive regulation of synapse maturation

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030426	growth cone
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003112 Olfactomedin-like
IPR003334 GPCR, family 2, latrophilin, C-terminal
IPR003924 GPCR, family 2, latrophilin
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497

PFAM