InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASD1

Summary

InnateDB Protein

IDBP-33018.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASD1

Protein Name

RAS, dexamethasone-induced 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225688

InnateDB Gene

IDBG-33016 (RASD1)

Protein Structure

UniProt Annotation

Function

Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues. {ECO:0000269PubMed:10673050, ECO:0000269PubMed:12818426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt