InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEF2C

Summary

InnateDB Protein

IDBP-33081.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEF2C

Protein Name

myocyte enhancer factor 2C

Synonyms

C5DELq14.3; DEL5q14.3;

Species

Homo sapiens

Ensembl Protein

ENSP00000340874

InnateDB Gene

IDBG-33077 (MEF2C)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0033613	activating transcription factor binding
GO:0035198	miRNA binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001568	blood vessel development
GO:0001649	osteoblast differentiation
GO:0001764	neuron migration
GO:0001782	B cell homeostasis
GO:0001947	heart looping
GO:0001958	endochondral ossification
GO:0001974	blood vessel remodeling
GO:0002062	chondrocyte differentiation
GO:0002224	toll-like receptor signaling pathway
GO:0002467	germinal center formation
GO:0002634	regulation of germinal center formation
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0002931	response to ischemia
GO:0003138	primary heart field specification
GO:0003139	secondary heart field specification
GO:0003151	outflow tract morphogenesis
GO:0003185	sinoatrial valve morphogenesis
GO:0003211	cardiac ventricle formation
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0007399	nervous system development
GO:0007507	heart development
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0007521	muscle cell fate determination
GO:0007611	learning or memory
GO:0009615	response to virus
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0014033	neural crest cell differentiation
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0014902	myotube differentiation
GO:0030182	neuron differentiation
GO:0030220	platelet formation
GO:0030224	monocyte differentiation
GO:0030279	negative regulation of ossification
GO:0030318	melanocyte differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030890	positive regulation of B cell proliferation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035690	cellular response to drug
GO:0035984	cellular response to trichostatin A
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042100	B cell proliferation
GO:0042692	muscle cell differentiation
GO:0043406	positive regulation of MAP kinase activity
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0045165	cell fate commitment
GO:0045652	regulation of megakaryocyte differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046928	regulation of neurotransmitter secretion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0048666	neuron development
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050853	B cell receptor signaling pathway
GO:0051145	smooth muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0051403	stress-activated MAPK cascade
GO:0051963	regulation of synapse assembly
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0055007	cardiac muscle cell differentiation
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060021	palate development
GO:0060025	regulation of synaptic activity
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060297	regulation of sarcomere organization
GO:0060536	cartilage morphogenesis
GO:0060998	regulation of dendritic spine development
GO:0061333	renal tubule morphogenesis
GO:0071222	cellular response to lipopolysaccharide
GO:0071277	cellular response to calcium ion
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0071498	cellular response to fluid shear stress
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071864	positive regulation of cell proliferation in bone marrow
GO:0072102	glomerulus morphogenesis
GO:0072160	nephron tubule epithelial cell differentiation
GO:0090073	positive regulation of protein homodimerization activity
GO:2000111	positive regulation of macrophage apoptotic process
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000727	positive regulation of cardiac muscle cell differentiation
GO:2000987	positive regulation of behavioral fear response
GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis
GO:2001016	positive regulation of skeletal muscle cell differentiation