InnateDB Protein
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IDBP-33101.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MOGAT3
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Protein Name
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monoacylglycerol O-acyltransferase 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368734
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InnateDB Gene
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IDBG-33097 (MOGAT3)
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Protein Structure
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Function |
Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. {ECO:0000269PubMed:12618427}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver. {ECO:0000269PubMed:12618427}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003846
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2-acylglycerol O-acyltransferase activity
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GO:0004144
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diacylglycerol O-acyltransferase activity
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86VF5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
346606
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UniGene |
Hs.512217
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RefSeq |
NP_001274076
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HUGO |
HGNC:23249
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OMIM |
610184
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CCDS |
CCDS75643
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HPRD |
11368
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IMGT |
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EMBL |
AC004876
AY229854
AY358200
BC100953
BC100954
BC100955
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GenPept |
AAD45832
AAI00954
AAI00955
AAI00956
AAO63579
AAQ88567
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