InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNHIT1

Summary

InnateDB Protein

IDBP-33180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNHIT1

Protein Name

zinc finger, HIT-type containing 1

Synonyms

CG1I; ZNFN4A1;

Species

Homo sapiens

Ensembl Protein

ENSP00000304593

InnateDB Gene

IDBG-33178 (ZNHIT1)

Protein Structure

UniProt Annotation

Function

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity. {ECO:0000269PubMed:17380123, ECO:0000269PubMed:17892483}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17892483}.

Disease Associations

Tissue Specificity

Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine. {ECO:0000269PubMed:17892483}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0031063	regulation of histone deacetylation
GO:0042129	regulation of T cell proliferation
GO:0070317	negative regulation of G0 to G1 transition