InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CX3CL1

Summary

InnateDB Protein

IDBP-33207.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CX3CL1

Protein Name

chemokine (C-X3-C motif) ligand 1

Synonyms

ABCD-3; C3Xkine; CXC3; CXC3C; fractalkine; neurotactin; NTN; NTT; SCYD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000006053

InnateDB Gene

IDBG-33205 (CX3CL1)

Protein Structure

UniProt Annotation

Function

The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269PubMed:21829356}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Processed fractalkine: Secreted.

Disease Associations

Tissue Specificity

Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0019221	cytokine-mediated signaling pathway
GO:0030593	neutrophil chemotaxis
GO:0030595	leukocyte chemotaxis
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0042060	wound healing
GO:0045766	positive regulation of angiogenesis
GO:0048246	macrophage chemotaxis
GO:0048247	lymphocyte chemotaxis
GO:0050729	positive regulation of inflammatory response
GO:0050902	leukocyte adhesive activation
GO:0051041	positive regulation of calcium-independent cell-cell adhesion
GO:0060055	angiogenesis involved in wound healing
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane