InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UQCRC1

Summary

InnateDB Protein

IDBP-33259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UQCRC1

Protein Name

ubiquinol-cytochrome c reductase core protein I

Synonyms

D3S3191; QCR1; UQCR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000203407

InnateDB Gene

IDBG-33257 (UQCRC1)

Protein Structure

UniProt Annotation

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008121	ubiquinol-cytochrome-c reductase activity
GO:0032403	protein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006119	oxidative phosphorylation
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
GO:0009060	aerobic respiration
GO:0014823	response to activity
GO:0022904	respiratory electron transport chain
GO:0043279	response to alkaloid
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005746	mitochondrial respiratory chain
GO:0005750	mitochondrial respiratory chain complex III